An inhibitor of mitochondrial dysfunction
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Mitochonic Acid 5

Item No. 35702

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[2-(2,4-difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic acid
CAS Number
1354707-41-7
Synonyms
  • MA-5
Molecular Formula
C18H13F2NO3
Formula Weight
329.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: 1 mg/ml
λmax
220 nm
SMILES
O=C(C(CC(C1=CC=C(C=C1F)F)=O)C2=CNC3=C2C=CC=C3)O
InChi Code
InChI=1S/C18H13F2NO3/c19-10-5-6-12(15(20)7-10)17(22)8-13(18(23)24)14-9-21-16-4-2-1-3-11(14)16/h1-7,9,13,21H,8H2,(H,23,24)
InChi Key
BOKQALWNGNLTOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $86

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    10 mg

    $154

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    25 mg

    $301

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    50 mg

    $513

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    Product Description

    Mitochonic acid 5 is an inhibitor of mitochondrial dysfunction.1 It increases intracellular ATP levels in Hep3B cells when used at a concentration of 3 µM. Mitochonic acid 5 (5 µM) rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells.2 It protects against decreases in cell viability induced by L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in fibroblasts isolated from patients with various mitochondrial diseases, including Leigh syndrome and Leber’s hereditary optic neuropathy (EC50s = 2.3-5.1 µM), in an electron transport chain-independent manner.1 Mitochonic acid 5 (50 mg/kg) reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, T., Yamaguchi, H., Kikusato, M., et al. Mitochonic acid 5 (MA-5), a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases. Tohoku J. Exp. Med. 236(3), 225-232 (2015).

    2. Tan, J., Chen, S.-X., Lei, Q.-Y., et al. Mitochonic acid 5 regulates mitofusin 2 to protect microglia. Neural Regen. Res. 16(9), 1813-1820 (2021).

    3. Suzuki, T., Yamaguchi, H., Kikusato, M., et al. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. J. Am. Soc. Nephrol. 27(7), 1925-1932 (2016).