A FASN inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TVB-2640

Item No. 35703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1H-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-benzonitrile
CAS Number
1399177-37-7
Synonyms
  • Denifanstat
  • Fatty Acid Synthase Inhibitor 2
  • FASN-IN-2
Molecular Formula
C27H29N5O
Formula Weight
439.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
231 nm
SMILES
N#CC1=CC=C(C2CCN(CC2)C(C3=CC(C4=NN=C(C)N4[H])=C(C5CCC5)C=C3C)=O)C=C1
InChi Code
InChI=1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31)
InChi Key
BBGOSBDSLYHMRA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $62

    Add

    5 mg

    $274

    Add

    10 mg

    $456

    Add

    25 mg

    $909

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    TVB-2640 is an inhibitor of fatty acid synthase (FASN; IC50 = 0.5 µM).1 It inhibits infection of an infectious-clone-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reporter virus in HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2; EC50 = 4 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syed-Abdul, M.M., Parks, E.J., Gaballah, A.H., et al. Fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities. Hepatology 72(1), 103-118 (2020).

    2. Chu, J., Xing, C., Du, Y., et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat. Metab. 3(11), 1466-1475 (2021).