An SHMT1 and SHMT2 inhibitor
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SHIN1

Item No. 35715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1′-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
CAS Number
2146095-85-2
Synonyms
  • RZ2994
Molecular Formula
C24H24N4O2
Formula Weight
400.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
256 nm
SMILES
N#CC1=C(N)OC2=C(C1(C(C)C)C3=CC(CO)=CC(C4=CC=CC=C4)=C3)C(C)=NN2
InChi Code
InChI=1S/C24H24N4O2/c1-14(2)24(20(12-25)22(26)30-23-21(24)15(3)27-28-23)19-10-16(13-29)9-18(11-19)17-7-5-4-6-8-17/h4-11,14,29H,13,26H2,1-3H3,(H,27,28)
InChi Key
VVVOFJZXKJKHTD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $515

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    Cayman Chemical
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    Product Description

    SHIN1 is an inhibitor of serine hydroxymethyltransferase 1 (SHMT1) and SHMT2 (IC50s = 5 and 13 nM, respectively).1 It inhibits proliferation of H1299 non-small cell lung cancer (NSCLC) cells overexpressing the proto-oncogene FRAT1 (IC50 = 0.6 µM). SHIN1 decreases tumor volume in an NSCLC mouse xenograft model using FRAT1-overexpressing H1299 cells when administered at a dose of 100 mg/kg three times a week.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, L., Endress, J., Cho, S., et al. Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Sci. Adv. 8(20), eabm8786 (2022).