A photosensitizer
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Talaporfin (sodium salt)

Item No. 35722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(7S,8S)-3-carboxy-7-(2-carboxyethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid, tetrasodium salt
CAS Number
220201-34-3
Synonyms
  • Mono-L-aspartyl Chlorin e6
  • NPe6
  • Taporfin
Molecular Formula
C38H37N5O9 • 4Na
Formula Weight
799.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: Sparingly soluble: 1-10 mg/mlPBS pH 7.2: Sparingly soluble: 1-10 mg/ml
SMILES
[O-]C(C[C@@H](C([O-])=O)NC(CC1=C2[C@H]([C@@H](C(C=C3NC(C(C=C)=C3C)=CC4=NC(C(CC)=C4C)=CC5=C(C)C(C([O-])=O)=C1N5)=N2)C)CCC([O-])=O)=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C38H41N5O9.4Na/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24;;;;/h7,12-14,18,22,30,39,43H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52);;;;/q;4*+1/p-4/b24-12?,25-13-,26-12-,27-14-,28-13?,29-14?,35-23?,36-23-;;;;/t18-,22-,30-;;;;/m0..../s1
InChi Key
KPALSRNVSRWOPA-XOAVSGGJSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $157

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    25 mg

    $367

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    50 mg

    $685

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    Cayman Chemical
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    Product Description

    Talaporfin is a photosensitizer.1 It induces apoptosis, DNA double-strand breaks (DSBs), and the production of reactive oxygen species (ROS) in TE-11R 5-fluorouracil-resistant esophageal squamous cell carcinoma (ESCC) cells when used at a concentration of 30 µg/ml in combination with radiation.2 Talaporfin (2.5, 5, and 10 mg/kg) in combination with photodynamic therapy (PDT) reduces tumor growth in a TE-11R ESCC mouse xenograft model. Formulations containing talaporfin have been used as photosensitizers in PDT for the treatment of endobronchial cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dennis, E.J., Dolmans, G.J., Fukumura, D., et al. Photodynamic therapy for cancer. Nature 3, 1-8 (2003).

    2. Ohashi, S., Kikuchi, O., Tsurumaki, M., et al. Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma. PLoS One 9(8), e103126 (2014).