A prodrug form of methylprednisolone
Related Products
Active Metabolite(s)
15013Methylprednisolone
Alternative(s)
118006α-Methylprednisolone 21-hemisuccinate
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

6α-Methylprednisolone 21-hemisuccinate (sodium salt)

Item No. 35742

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6α,11β)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione, monosodium salt
CAS Number
2375-03-3
Synonyms
  • Methylprednisolone 21-succinate
  • MPS
  • NSC 48989
  • U-9088
Molecular Formula
C26H33O8 • Na
Formula Weight
496.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: Slightly solublePBS (pH 7.2): 1 mg/ml
λmax
242 nm
SMILES
O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC(O)=O)=O)=O)=C1.[Na]
InChi Code
InChI=1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
InChi Key
WOARBZBOZOGFGA-SGJOWKDISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $37

    Add

    25 mg

    $73

    Add

    50 mg

    $136

    Add

    100 mg

    $252

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    6α-Methylprednisolone 21-hemisuccinate is a prodrug form of the synthetic glucocorticoid methylprednisolone (Item No. 15013).1 It is converted to methylprednisolone by carboxylesterase 2 (CES2).2 Nanoliposomes containing 6α-methylprednisolone 21-hemisuccinate decrease disease severity in a rat model of adjuvant-induced arthritis.3 Formulations containing 6α-methylprednisolone 21-hemisuccinate have been used as anti-inflammatory agents and immunosuppressants with indications in allergic reactions and dermatologic, renal, gastrointestinal, respiratory, and ophthalmic diseases, as well as endocrine, hematologic, and rheumatic disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vree, T.B., Lagerwerf, A.J., Verwey-van Wissen, C.P., et al. High-performance liquid chromatography analysis, preliminary pharmacokinetics, metabolism and renal excretion of methylprednisolone with its C6 and C20 hydroxy metabolites in multiple sclerosis patients receiving high-dose pulse therapy. J. Chromatogr. B Biomed. Sci. Appl. 732(2), 337-348 (1999).

    2. Hori, T., Jin, L., Fujii, A., et al. Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene. Xenobiotica 42(7), 614-623 (2012).

    3. Avnir, Y., Ulmansky, R., Wasserman, V., et al. Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: A novel approach to treating autoimmune arthritis. Arthritis Rheum. 58(1), 119-129 (2008).