An amino acid conjugate
Related Products
Isomer(s)
27657Dityrosine (hydrochloride)
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L,L-Dityrosine

Item No. 35746

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α3S,α3′S-diamino-6,6′-dihydroxy-[1,1′-biphenyl]-3,3′-dipropanoic acid
CAS Number
63442-81-9
Molecular Formula
C18H20N2O6
Formula Weight
360.4
Purity
≥90%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
OC1=CC=C(C[C@H](N)C(O)=O)C=C1C2=CC(C[C@H](N)C(O)=O)=CC=C2O
InChi Code
InChI=1S/C18H20N2O6/c19-13(17(23)24)7-9-1-3-15(21)11(5-9)12-6-10(2-4-16(12)22)8-14(20)18(25)26/h1-6,13-14,21-22H,7-8,19-20H2,(H,23,24)(H,25,26)/t13-,14-/m0/s1
InChi Key
OQALFHMKVSJFRR-KBPBESRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $42

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    1 mg

    $80

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    5 mg

    $179

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    10 mg

    $293

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    Product Description

    L,L-Dityrosine is an amino acid conjugate containing two L-tyrosine molecules. L-Tyrosine residues in fibrinogen proteins can form L,L-dityrosine cross-links between fibrinogen proteins in the presence of hematin and plasma-generated hydrogen peroxide under non-thermal plasma exposure.1 L-Tyrosine residues in human, but not mouse, amylin peptides can form L,L-dityrosine cross-links between amylin peptides in the presence of copper (II) ions and hydrogen peroxide.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ke, Z., and Huang, Q. Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: One important mechanism of facilitated blood coagulation. Sci. Rep. 6, 26982 (2016).

    2. Dong, X., Svantesson, T., Sholts, S.B., et al. Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin). Biochem. Biophys. Res. Commun. 510(4), 520-524 (2019).