A cell-permeable fluorescent thallium indicator
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Thallos AM

Item No. 35755

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[4-[[[3′,6′-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl]carbonyl]amino]-2-methoxyphenyl]-glycine, (acetyloxy)methyl ester
CAS Number
1802991-71-4
Synonyms
  • Thallos Acetoxymethyl ester
Molecular Formula
C42H36N2O17
Formula Weight
840.7
Purity
≥95%
Emission
515 nm
Excitation
490 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C)OC1=CC=C2C3(C(C=CC(C(N([H])C4=CC(OC)=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=C4)=O)=C5)=C5C(O3)=O)C6=CC=C(OC(C)=O)C=C6OC2=C1
InChi Code
InChI=1S/C42H36N2O17/c1-22(45)54-20-56-38(49)18-44(19-39(50)57-21-55-23(2)46)34-13-7-27(15-37(34)53-5)43-40(51)26-6-10-31-30(14-26)41(52)61-42(31)32-11-8-28(58-24(3)47)16-35(32)60-36-17-29(59-25(4)48)9-12-33(36)42/h6-17H,18-21H2,1-5H3,(H,43,51)
InChi Key
GEIWLXJYBWGYES-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 x 50 µg

    $690

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    500 µg

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    Product Description

    Thallos AM is a cell-permeable fluorescent thallium indicator that has been used to measure the activity of sodium or potassium channels.1,2 It can also be used for transporters and G protein-coupled receptors (GPCRs). It displays excitation/emission maxima of 490/515 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, Y., Days, E., Romaine, I., et al. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem. Neurosci. 6(6), 871-878 (2015).

    2. Dutter, B.F., Ender, A., Sulikowski, G.A., et al. Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org. Biomol. Chem. 16(31), 5575-5579 (2018).