A γ-secretase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BMS-299897

Item No. 35777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid
CAS Number
290315-45-6
Molecular Formula
C24H21ClF3NO4S
Formula Weight
511.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
C[C@H](C1=C(C=C(C=C1)F)CCCC(O)=O)N(C2=C(C=CC(F)=C2)F)S(=O)(C3=CC=C(C=C3)Cl)=O
InChi Code
InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1
InChi Key
IZAOBRWCUGOKNH-OAHLLOKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $125

    Add

    10 mg

    $186

    Add

    25 mg

    $310

    Add
    Product Description

    BMS-299897 is an inhibitor of γ-secretase.1,2,3 It selectively cleaves the carboxy terminal fragment (CTF) of amyloid precursor protein (APP) over the Notch-1 CTF in HEK293 cells (IC50s = 7.1 and 105.9 nM, respectively).2 BMS-299897 (0.1-1 nmol/animal) reduces increases in amyloid-β (1-42) (Aβ42) levels induced by Aβ (25-35) in the mouse hippocampus.3 It also prevents deficits induced by Aβ (25-35) in the novel object recognition test when tested with a one-hour, but not a 24-hour, intertrial interval in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tian, G., Sobotka-Briner, C.D., Zysk, J., et al. Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines. The Journal of Biological Chemisty 277(35), 31499-31505 (2002).

    2. Barten, D.M., Guss, V.L., Corsa, J.A., et al. Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor. J. Pharmacol. Exp. Ther. 312(2), 635-643 (2005).

    3. Meunier, J., Villard, V., Givalois, L., et al. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer’s disease. Eur. J. Pharmacol. 698(1-3), 193-199 (2013).