A metabolite of glycine and precursor in the biosynthesis of creatine
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Glycocyamine

Item No. 35792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(aminoiminomethyl)-glycine
CAS Number
352-97-6
Synonyms
  • GAA
  • Guanidinoacetic Acid
  • Guanidinoacetate
  • NSC 1901
  • NSC 227847
  • NSC 26360
Molecular Formula
C3H7N3O2
Formula Weight
117.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
O=C(CN([H])C(N)=N)O
InChi Code
InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6)
InChi Key
BPMFZUMJYQTVII-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $37

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    50 g

    $99

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    100 g

    $128

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    250 g

    $270

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    Product Description

    Glycocyamine is a metabolite of glycine and precursor in the biosynthesis of creatine.1,2 It is formed from glycine by glycine amidinotransferase (GATM) in the kidney and pancreas, transported to the liver, and methylated by guanidinoacetate N-methyltransferase (GAMT) to form creatine.1 Levels of glycocyamine are altered in individuals with cerebral creatine deficiency syndromes (CCDSs), inborn errors of metabolism characterized by deficiencies in GATM or GAMT.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ostojic, S.M. Cellular bioenergetics of guanidinoacetic acid: The role of mitochondria. J. Bioenerg. Biomembr. 47(5), 369-372 (2015).

    2. Portocarero, N., and Braun, U. The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickens. Poult. Sci. 100(7), 101203 (2021).

    3. Stockler, S., Schutz, P.W., and Salomons, G.S. Cerebral creatine deficiency syndromes: Clinical aspects, treatment and pathophysiology. Subcell. Biochem. 46, 149-166 (2007).