An active metabolite of temozolomide
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Parent Compound(s)
14163Temozolomide
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Temozolomide Acid

Item No. 35800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic acid
CAS Number
113942-30-6
Synonyms
  • Temozolomide 8-Carboxylic Acid
  • TMZA
Molecular Formula
C6H5N5O3
Formula Weight
195.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
252, 324 nm
SMILES
O=C(C(N=CN12)=C2N=NN(C)C1=O)O
InChi Code
InChI=1S/C6H5N5O3/c1-10-6(14)11-2-7-3(5(12)13)4(11)8-9-10/h2H,1H3,(H,12,13)
InChi Key
VVTMIOYTNALQAW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $62

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    50 mg

    $93

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    100 mg

    $123

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    250 mg

    $244

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    Cayman Chemical
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    Product Description

    Temozolomide acid is an active metabolite of the alkylating agent precursor temozolomide (Item No. 14163).1 It is cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner. Temozolomide acid is also a synthetic intermediate in the synthesis of temozolomide prodrugs with anticancer activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsang, L.L.H., Farmer, P.B., Gescher, A., et al. Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity. Cancer Chemother. Pharmacol. 26(6), 429-436 (1990).

    2. Liu, D., Yang, J.-G., Cheng, J., et al. Synthesis and antitumor activity of 3-methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamides. Molecules 15(12), 9427-9437 (2010).