A FEN1 inhibitor
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LNT 1

Item No. 35803

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS Number
824983-91-7
Molecular Formula
C15H12N2O5S
Formula Weight
332.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mLDMSO: 10 mg/mLEthanol: 4 mg/mLPBS (pH 7.2): 0.11 mg/mL
SMILES
O=C1C2=C(N(CC3OC4=C(OC3)C=CC=C4)C(N1O)=O)C=CS2
InChi Code
InChI=1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2
InChi Key
MXQGCMQXTPTJJT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $121

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    10 mg

    $179

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    Cayman Chemical
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    Product Description

    LNT 1 is an inhibitor of flap endonuclease 1 (FEN1; IC50 = 0.011 µM).1 It is selective for FEN1 over xeroderma pigmentosum G (IC50 = 0.292 µM). LNT 1 (3 and 6 µM) enhances methyl methanesulfonate-induced DNA damage and cell death in T24 bladder cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tumey, N., Bom, D., Huck, B., et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg. Med. Chem. Lett. 15(2), 277-281 (2005).