A trypanocide
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Dimidium (bromide)

Item No. 35816

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,8-diamino-5-methyl-6-phenyl-phenanthridinium, monobromide
CAS Number
518-67-2
Synonyms
  • Phenanthridinium Compound 1553
Molecular Formula
C20H18N3 • Br
Formula Weight
380.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
214, 295 nm
SMILES
NC1=CC2=C(C3=C([N+](C)=C2C4=CC=CC=C4)C=C(N)C=C3)C=C1.[Br-]
InChi Code
InChI=1S/C20H17N3.BrH/c1-23-19-12-15(22)8-10-17(19)16-9-7-14(21)11-18(16)20(23)13-5-3-2-4-6-13;/h2-12,22H,21H2,1H3;1H
InChi Key
MQOKYEROIFEEBH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Cayman Chemical
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    Product Description

    Dimidium is a trypanocide.1,2 In vivo, dimidium (0.25-0.7 mg/kg) reduces parasite burden in T. congolense-infected mice.1 It also completely clears trypanosomes from the peripheral blood in zebu oxen naturally infected with T. congolense when administered intramuscularly at a dose of 0.75 mg/kg.2 Formulations containing dimidium have previously been used in the treatment of trypanosomiasis in cattle.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Woolfe, G. The trypanocidal action of phenanthridine compounds. Ann. Trop. Med. Parasitol. 46(4), 285-288 (1952).

    2. Wilde, J.K.H. Experimental use of dimidium bromide (1553) in the treatment of T. congolense infection in the zebu cattle. J. Comp. Pathol. Ther. 59(1), 48-53 (1949).