A P2X7 receptor antagonist
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AZ 10606120 (hydrochloride)

Item No. 35820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-tricyclo[3.3.1.13,7]decane-1-acetamide, dihydrochloride
CAS Number
607378-18-7
Molecular Formula
C25H34N4O2 • 2HCl
Formula Weight
495.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleWater: soluble
SMILES
O=C(CC12CC3CC(C2)CC(C1)C3)NC4=CC=CC5=NC(NCCNCCO)=CC=C54.Cl.Cl
InChi Code
InChI=1S/C25H34N4O2.2ClH/c30-9-8-26-6-7-27-23-5-4-20-21(28-23)2-1-3-22(20)29-24(31)16-25-13-17-10-18(14-25)12-19(11-17)15-25;;/h1-5,17-19,26,30H,6-16H2,(H,27,28)(H,29,31);2*1H
InChi Key
BVFONFUUWORSPO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $556

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    Cayman Chemical
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    Product Description

    AZ 10606120 is an antagonist of the purinergic P2X7 receptor (IC50 = 10 nM).1 It reduces cell migration and proliferation of PANC-1 pancreatic ductal adenocarcinoma cells when used at a concentration of 10 µM.2 AZ 10606120 (0.01 µg/kg) reduces cecal slurry-induced impairment of endothelial-dependent relaxation but increases spleen bacterial burden in a mouse model of polymicrobial sepsis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guile, S.D., Alcaraz, L., Birkinshaw, T.N., et al. Antagonists of the P2X7 receptor. From lead identification to drug development. J. Med. Chem. 52(10), 3123-3141 (2009).

    2. Giannuzzo, A., Pedersen, S.F., and Novak, I. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol. Cancer 14, 203 (2015).

    3. Meegan, J.E., Komalavilas, P., Cheung-Flynn, J., et al. Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis. Physiol. Rep. 10(11), e15290 (2022).