Tubercidin

Tubercidin is a nucleoside analog that has been found in S. tubercidicus and has diverse biological activities.^1,2,3,4 It is active against S. faecalis (IC₅₀ = 0.02 µM) and cytotoxic to P388 murine leukemia and A549 human lung adenocarcinoma cells (IC₅₀s = 0.008 and 0.019 µg/ml, respectively).^1,2 Tubercidin reduces infection of Calu-3 cells by severe acute respiratory coronavirus 2 (SARS-CoV-2; EC₅₀ = 0.05 µM) but is toxic to A549 cells expressing human ACE2 (A549-ACE2) and Vero cells.³ Tubercidin (5 mg/kg per day), in combination with the nucleoside transport inhibitor prodrug NBMPR-P, increases survival in a mouse model of schistosomiasis but is hepato- and nephrotoxic and induces mortality when administered alone at the same dose for four days.⁴

WARNING This product is not for human or veterinary use.

1. Bloch, A., Leonard, R.J., and Nichol, C.A. On the mode of action of 7-deaza-adenosine (tubercidin). Biochim. Biophys. Acta 138(1), 10-25 (1967).

2. Biabani, M.F., Gunasekera, S.P., Longley, R.E., et al. Tubercidin, a cytotoxic agent from the marine sponge Caulospongia biflabellata. Pharm. Biol. 40(4), 302-303 (2002).

3. Schultz, D.C., Johnson, R.M., Ayyanathan, K., et al. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature 604(7904), 134-140 (2022).

4. el Kouni, M.H., Diop, D., O'Shea, P., et al. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob. Agents Chemother. 33(6), 824-827 (1989).