A GID1 inhibitor
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TSPC

Item No. 35837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-thienylsulfonyl)-2-pyrazinecarbonitrile
CAS Number
882286-32-0
Molecular Formula
C9H5N3O2S2
Formula Weight
251.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/ml
λmax
221, 274 nm
SMILES
N#CC1=NC=CN=C1S(=O)(C2=CC=CS2)=O
InChi Code
InChI=1S/C9H5N3O2S2/c10-6-7-9(12-4-3-11-7)16(13,14)8-2-1-5-15-8/h1-5H
InChi Key
HGCFMGDVMNCLNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Product Description

    TSPC is an inhibitor of the gibberellin receptor GID1.1 It inhibits the gibberellin-induced interaction between the gibberellin receptor GID1 and a negative regulator of its signaling, DELLA, in a yeast two-hybrid assay (IC50 = <30 µM) and gibberellin binding to GID1 in the presence or absence of DELLA in a cell-free assay when used at concentrations ranging from 1 to 100 µM. TSPC (10-100 µM) suppresses seed germination and seedling growth in Arabidopsis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoon, J.-M., Nakajima, M., Mashiguchi, K., et al. Chemical screening of an inhibitor for gibberellin receptors based on a yeast two-hybrid system. Bioorg. Med. Chem. Lett. 23(4), 1096-1098 (2013).