An antiviral agent
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GLS4

Item No. 35843

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-5-pyrimidinecarboxylic acid, ethyl ester
CAS Number
1092970-12-1
Synonyms
  • Morphothiadin
Molecular Formula
C21H22BrFN4O3S
Formula Weight
509.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 1 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.3 mg/ml
SMILES
O=C(C1=C(CN2CCOCC2)N=C(C3=NC=CS3)NC1C4=CC=C(C=C4Br)F)OCC
InChi Code
InChI=1S/C21H22BrFN4O3S/c1-2-30-21(28)17-16(12-27-6-8-29-9-7-27)25-19(20-24-5-10-31-20)26-18(17)14-4-3-13(23)11-15(14)22/h3-5,10-11,18H,2,6-9,12H2,1H3,(H,25,26)
InChi Key
SQGRDKSRFFUBBU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    GLS4 is an antiviral agent.1 It inhibits the replication of wild-type hepatitis B virus (HBV) and the drug-resistant HBV strains rtA181T, rtA181V, and rtN236T (IC50s = 146, 145, 161, and 131 nM, respectively). GSL4 (1 and 10 µM) inhibits the formation of viral capsids and decreases viral core protein levels in HBV-infected HepG2 and HepG2.2.15 cells. It inhibits HBV replication and reduces the levels of viral intracellular core antigens in mice inoculated with HepAD38 cells, which carry and replicate HBV, when administered at doses ranging from 7.5 to 60 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X.-Y., Wei, Z.-M., Wu, G.-Y., et al. In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. Antivir. Ther. 17(5), 793-803 (2012).

    2. Wu, G., Liu, B., Zhang, Y., et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob. Agents Chemother. 57(11), 5344-5354 (2013).