An antimicrobial peptide
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Indolicidin (trifluoroacetate salt)

Item No. 35845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucyl-L-leucyl-L-prolyl-L-tryptophyl-L-lysyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-L-argininamide, trifluoroacetate salt
Synonyms
  • ILPWKWPWWPWRR-NH2
Molecular Formula
C100H132N26O13 • XCF3COOH
Formula Weight
1906.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): insol
λmax
272 nm
SMILES
NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCN3C([C@H](CC4=CNC5=C4C=CC=C5)NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@@H]8CCCN8C([C@H](CC9=CNC%10=C9C=CC=C%10)NC([C@H](CCCCN[H])NC([C@H](CC%11=CNC%12=C%11C=CC=C%12)NC([C@@H]%13CCCN%13C([C@@H](NC([C@](N[H])([H])[C@@H](C)CC)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C100H132N26O13.C2HF3O2/c1-5-57(4)85(102)95(136)123-79(45-56(2)3)96(137)124-42-20-36-82(124)92(133)118-76(46-58-51-110-68-28-11-6-23-63(58)68)89(130)116-74(33-16-17-39-101)88(129)121-80(49-61-54-113-71-31-14-9-26-66(61)71)97(138)125-43-21-38-84(125)94(135)120-78(48-60-53-112-70-30-13-8-25-65(60)70)91(132)122-81(50-62-55-114-72-32-15-10-27-67(62)72)98(139)126-44-22-37-83(126)93(134)119-77(47-59-52-111-69-29-12-7-24-64(59)69)90(131)117-75(35-19-41-109-100(106)107)87(128)115-73(86(103)127)34-18-40-108-99(104)105;3-2(4,5)1(6)7/h6-15,23-32,51-57,73-85,110-114H,5,16-22,33-50,101-102H2,1-4H3,(H2,103,127)(H,115,128)(H,116,130)(H,117,131)(H,118,133)(H,119,134)(H,120,135)(H,121,129)(H,122,132)(H,123,136)(H4,104,105,108)(H4,106,107,109);(H,6,7)/t57-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-;/m0./s1
InChi Key
HQRSBAXSXVGIBJ-MSEKKQLVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Indolicidin is an antimicrobial peptide.1 It is active against multidrug-resistant isolates of enteroaggregative E. coli (MDR-EAEC; MICs = 32 µM for all). Indolicidin is also active against S. cerevisiae, T. beigelii, and C. albicans (MICs = 5-10, 2.5-5, and 5-10 µM, respectively) and reduces viral replication of HIV-1 in MT-2 cells when used at concentrations ranging from 67 to 100 µg/ml.2,3 In vivo, indolicidin increases survival of MDR-EAEC-infected G. mellonella larvae.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vergis, J., Malik, S.S., Pathak, R., et al. Antimicrobial efficacy of indolicidin against multi-drug resistant enteroaggregative Escherichia coli in a Galleria mellonella model. Front. Microbiol. 10, 2723 (2019).

    2. Lee, D.G., Kim, H.K., Kim, S.A., et al. Fungicidal effect of indolicidin and its interaction with phospholipid membranes. Biochem. Biophys. Res. Commun. 305(2), 305-310 (2003).

    3. Robinson, W.E., Jr., McDougall, B., Tran, D., et al. Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils. J. Leukoc. Biol. 63(1), 94-100 (1998).