An anti-inflammatory peptide
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F1 (trifluoroacetate salt)

Item No. 35846

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Tat-IKIP (46-60)
  • Tat-Inhibitor of NF-κB Kinase-interacting Peptide
Molecular Formula
C145H246N48O31S • XCF3COOH
Formula Weight
3189.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRLLSLAMTLGLAWLVF-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC1=CC=C(O)C=C1)N[H])=O)=O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@]([H])([C@@H](C)O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C145H246N48O31S.C2HF3O2/c1-75(2)62-102(119(203)170-73-113(199)174-103(63-76(3)4)130(214)171-83(16)117(201)184-108(70-87-71-168-91-37-23-22-36-89(87)91)134(218)187-107(67-80(11)12)135(219)192-114(81(13)14)137(221)190-109(139(223)224)69-85-34-20-19-21-35-85)189-138(222)115(84(17)195)193-129(213)101(52-61-225-18)175-116(200)82(15)172-131(215)104(64-77(5)6)188-136(220)110(74-194)191-133(217)106(66-79(9)10)186-132(216)105(65-78(7)8)185-127(211)99(45-33-60-167-145(160)161)181-124(208)96(42-30-57-164-142(154)155)179-125(209)97(43-31-58-165-143(156)157)182-128(212)100(50-51-111(149)197)183-126(210)98(44-32-59-166-144(158)159)180-123(207)95(41-29-56-163-141(152)153)178-122(206)94(39-25-27-54-147)177-121(205)93(38-24-26-53-146)176-120(204)92(40-28-55-162-140(150)151)173-112(198)72-169-118(202)90(148)68-86-46-48-88(196)49-47-86;3-2(4,5)1(6)7/h19-23,34-37,46-49,71,75-84,90,92-110,114-115,168,194-196H,24-33,38-45,50-70,72-74,146-148H2,1-18H3,(H2,149,197)(H,169,202)(H,170,203)(H,171,214)(H,172,215)(H,173,198)(H,174,199)(H,175,200)(H,176,204)(H,177,205)(H,178,206)(H,179,209)(H,180,207)(H,181,208)(H,182,212)(H,183,210)(H,184,201)(H,185,211)(H,186,216)(H,187,218)(H,188,220)(H,189,222)(H,190,221)(H,191,217)(H,192,219)(H,193,213)(H,223,224)(H4,150,151,162)(H4,152,153,163)(H4,154,155,164)(H4,156,157,165)(H4,158,159,166)(H4,160,161,167);(H,6,7)/t82-,83-,84+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,114-,115-;/m0./s1
InChi Key
XYMHNJDFCXDIDL-ULANDUPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    F1 is an anti-inflammatory peptide composed of the HIV-1 Tat protein transduction domain linked to a 15-amino acid peptide corresponding to residues 46-60 of inhibitor of NF-κB kinase-interacting peptide (IKIP).1 It inhibits LPS-induced phosphorylation of IκB kinase α (IKKα) and IKKβ and nuclear translocation of NF-κB (p65) in isolated mouse peritoneal macrophages when used at a concentration of 5 µM. In vivo, F1 (5 mg/kg) decreases serum levels of IL-6, TNF-α, and IL-1β and increases survival in a mouse model of LPS-induced sepsis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H., Yan, Z., Zhao, Y., et al. A peptide derived from IKK-interacting protein attenuates NF-κB activation and inflammation. J. Immunol. 207(6), 1652-1661 (2021).