A phytosterol with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Clerosterol

Item No. 35862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,24S)-stigmasta-5,25-dien-3-ol
CAS Number
2364-23-0
Synonyms
  • (-)-Clerosterol
  • NSC 144945
  • Δ5,25-Stigmastadienol
Molecular Formula
C29H48O
Formula Weight
412.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
THF: Soluble
SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@H](CC)C(C)=C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
InChi Code
InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,20-21,23-27,30H,2,7-9,11-18H2,1,3-6H3/t20-,21+,23+,24+,25-,26+,27+,28+,29-/m1/s1
InChi Key
GHGKPLPBPGYSOO-FBZNIEFRSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $369

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Clerosterol is a phytosterol that has been found in C. fragile and has diverse biological activities.1,2 It is active against T. b. brucei (IC50 = 53.6 µg/ml).1 Clerosterol inhibits the proliferation of A2058 melanoma cells (IC50 = 150 µM).2 It induces apoptosis, cell cycle arrest at the sub-G1 phase, and mitochondrial membrane depolarization in A2058 cells when used at a concentration of 150 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoet, S., Pieters, L., Muccioli, G.G., et al. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J. Nat. Prod. 70(8), 1360-1363 (2007).

    2. Kim, A.D., Lee, Y., Kang, S.-H., et al. Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells. Mar. Drugs 11(2), 418-430 (2013).