A chemotactic peptide
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Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation

N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (trifluoroacetate salt)

Item No. 35865

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-formyl-L-norleucyl-L-leucyl-L-phenylalanyl-L-norleucyl-L-tyrosyl-L-lysine, monotrifluoroacetate salt
CAS Number
2918767-97-0
Synonyms
  • fNLFNYK
Molecular Formula
C43H65N7O9 • CF3COOH
Formula Weight
938.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CCCC[C@H](NC=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCC)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC1=CC=C(C=C1)O)=O)=O)CC2=CC=CC=C2)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C43H65N7O9.C2HF3O2/c1-5-7-16-32(45-27-51)38(53)48-35(24-28(3)4)40(55)50-36(25-29-14-10-9-11-15-29)41(56)46-33(17-8-6-2)39(54)49-37(26-30-19-21-31(52)22-20-30)42(57)47-34(43(58)59)18-12-13-23-44;3-2(4,5)1(6)7/h9-11,14-15,19-22,27-28,32-37,52H,5-8,12-13,16-18,23-26,44H2,1-4H3,(H,45,51)(H,46,56)(H,47,57)(H,48,53)(H,49,54)(H,50,55)(H,58,59);(H,6,7)/t32-,33-,34-,35-,36-,37-;/m0./s1
InChi Key
PIIHXDKVEVMPFE-KPIXKXSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $104

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    10 mg

    $192

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    25 mg

    $439

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    Product Description

    N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fNLFNYK) is a synthetic chemotactic peptide.1,2 It binds to the formyl peptide receptor (FPR; Kd = 2.2 nM).1 fNLFNYK has been conjugated to various fluorophores to monitor FPR internalization.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niedel, J.E. The formyl peptide chemotactic receptor: Cellular processing of peptide and receptor. Receptor-Mediated Endocytosis. Receptors and Recognition 15, 273-299 (1983).

    2. Boulay, F., Tardif, M., Brouchon, L., et al. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem. Biophys. Res. Commun. 168(3), 1103-1109 (1990).

    3. Yan, P., Nanamori, M., Sun, M., et al. The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J. Immunol. 177(10), 7050-7058 (2006).