A 5-HT4 partial agonist
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Usmarapride (oxalate)

Item No. 35867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-1H-indazol, monoethanedioate
CAS Number
1428862-33-2
Synonyms
  • SUVN-D4010
Molecular Formula
C21H29N5O2 • C2H2O4
Formula Weight
473.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C(O)=O)O.CC(C)N(C1=C2C=CC=C1)N=C2C3=NN=C(C4CCN(CC4)CCCOC)O3
InChi Code
InChI=1S/C21H29N5O2.C2H2O4/c1-15(2)26-18-8-5-4-7-17(18)19(24-26)21-23-22-20(28-21)16-9-12-25(13-10-16)11-6-14-27-3;3-1(4)2(5)6/h4-5,7-8,15-16H,6,9-14H2,1-3H3;(H,3,4)(H,5,6)
InChi Key
XHXCJKNEBFAUSE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $293

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    10 mg

    $520

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    Product Description

    Usmarapride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4.1 It induces reporter gene expression in CHO cells expressing recombinant human 5-HT4E receptors (EC50 = 44 nM). In vivo, usmarapride (1 and 3 mg/kg) increases novel object exploration time in rats. It also reverses scopolamine-induced memory deficits in rats when administered at doses of 1, 3, and 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nirogi, R., Mohammed, A.R., Shinde, A.K., et al. Discovery and preclinical characterization of usmarapride (SUVN-D4010): A potent, selective 5-HT4 receptor partial agonist for the treatment of cognitive deficits associated with Alzheimer’s disease. J. Med. Chem. 64(15), 10641-10665 (2021).