Active • Host: E. coli • AA: 209-426 • Tag: N-terminal GST; C-terminal His • MW: 52 kDa
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TEAD1 Cofactor-Binding Domain (human, recombinant)

Item No. 35888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • NTEF-1
  • SV40
  • TEA Domain Family Member 1
  • TEA Domain Transcriptional Factor 1
  • TEF-1
  • Transcriptional Enhancer Factor 1
Purity
≥85% estimated by SDS-PAGE
Source
Active recombinant human N-terminal GST- and C-terminal His-tagged TEAD1 cofactor-binding domain expressed in E. coli
Amino Acids
209-426
MW
52 kDa
Formulation (Request formulation change)
50 mM HEPES pH 7.0, with 100 mM sodium chloride, 1 mM DTT, and 10% glycerol
UniProt Accession №
P28347
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $604

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    Product Description

    TEA domain transcription factor 1 (TEAD1) is a transcription factor and member of the TEA domain-containing family of transcription factors.1 It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds TAZ, YES-associated transcriptional regulator (YAP), vestigial-like proteins (VGLLs), and several other cofactors. Lipidation of the TEAD1 CBD increases TAZ- or YAP-dependent transcriptional activity.2 TEAD1 is expressed in late embryonic development and adult tissues.3 It is involved in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death.1 TEAD1 is specifically involved in cardiomyocyte and vascular smooth muscle cell proliferation, myogenesis, gliosis, osteoclastogenesis, and progenitor stemness, among other processes.4,5 TEAD1 containing a tyrosine-to-histidine mutation at position 421 (TEAD1Y421H) is associated with Sveinsson’s chorioretinal atrophy.6 Increased nuclear tumor levels of TEAD1 are associated with decreased disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC).7 Cayman’s TEAD1 Cofactor-Binding Domain (human, recombinant) protein can be used for binding assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Landin-Malt, A., Benhaddou, A., Zider, A., et al. An evolutionary, structural and functional overview of the mammalian TEAD1 and TEAD2 transcription factors. Gene 591(1), 292-303 (2016).

    2. Noritsugu, K., Suzuki, T., Dodo, K., et al. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell Rep. 42(4), 112388 (2023).

    3. Kaneko, K.J., and DePamphilis, M.L. Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. Dev Genet. 22(1), 43-55 (1998).

    4. Currey, L., Thor, S., and Piper, M. TEAD family transcription factors in development and disease. Development 148(12), dev196675 (2021).

    5. Figeac, N., Mohamed, A.D., Sun, C., et al. VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle. J. Cell Sci. 132(13), jcs225946 (2019).

    6. Fossdal, R., Jonasson, F., Kristjansdottir, G.T., et al. A novel TEAD1 mutation is the causative allele in Sveinsson’s chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration). Hum. Mol. Genet. 13(9), 975-981 (2004).

    7. Drexler, R., Fahy, R., Küchler, M., et al. Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma. Pancreatology 21(1), 170-179 (2021).