An agonist of group I mGluRs
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Isomer(s)
14411(S)-3,5-DHPG
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(R,S)-3,5-DHPG

Item No. 35912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-3,5-dihydroxy-benzeneacetic acid
CAS Number
146255-66-5
Synonyms
  • DL-3,5-Dihydroxyphenylglycine
  • (R,S)-3,5-Dihydroxyphenylglycine
Molecular Formula
C8H9NO4
Formula Weight
183.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlWater: 1 mg/ml
SMILES
O=C(C(C1=CC(O)=CC(O)=C1)N)O
InChi Code
InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
InChi Key
HOOWCUZPEFNHDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    (R,S)-3,5-DHPG is an agonist of group I metabotropic glutamate receptors (mGluRs).1 It induces phosphoinositol hydrolysis in MCB3901, also known as AV12-664, cells expressing human mGluR1a and mGluR5a in a concentration-dependent manner. (R,S)-3,5-DHPG (10 µM) potentiates NMDA-induced depolarizations in rat hippocampal slices. Intrathecal administration of (R,S)-3,5-DHPG (300 nmol/animal) increases mean blood pressure in anesthetized rats.2 Intracerebroventricular administration of (R,S)-3,5-DHPG (1.5 µmol/animal) induces seizures in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fitzjohn, S.M., Bortolotto, Z.A., Palmer, M.J., et al. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology 37(12), 144-1458 (1998).

    2. S.M., C., and García, M.d.C. Activation of spinal metabotropic glutamate receptors elicits cardiovascular responses in pentobarbital anesthetized rats. Naunyn Schmiedebergs Arch Pharmacol. 366(4), 343-349 (2002).

    3. Camón, L., Vives, P., de Vera, N., et al. Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine. J. Neurosci. Res. 51(3), 339-348 (1998).