A nucleoside precursor
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6-Chloropurine Riboside

Item No. 36002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-9-β-D-ribofuranosyl-9H-purine
CAS Number
5399-87-1
Synonyms
  • NSC 4910
Molecular Formula
C10H11ClN4O4
Formula Weight
286.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/ml
SMILES
ClC1=C(N=CN2[C@]3([H])O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1
InChi Code
InChI=1S/C10H11ClN4O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2/t4-,6-,7-,10-/m1/s1
InChi Key
XHRJGHCQQPETRH-KQYNXXCUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $98

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    5 g

    $367

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    Cayman Chemical
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    Product Description

    6-Chloropurine riboside is a nucleoside precursor.1 It has been used in the synthesis of adenosine derivatives with antiproliferative activity in human gastric cancer cells expressing the adenosine A3 receptor. 6-Chloropurine riboside has also been used in the synthesis of N6-benzyladenosine derivatives with antiproliferative activity in a variety of cancer cells or inhibitory activity against T. gondii replication in CRL-1634/Hs27 human skin fibroblasts.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zurita, F.V., Vega, N.B., and Cabrera, M.G. Semisynthesis, characterization and evaluation of new adenosine derivatives as antiproliferative agents. Molecules 23(5), 1111 (2018).

    2. Dolezal, K., Popa, I., Hauserová, E., et al. Preparation, biological activity and endogenous occurrence of N6-benzyladenosines. Bioorg. Med. Chem. 15(11), 3737-3747 (2007).

    3. Kim, Y.A., Sharon, A., Chu, C.K., et al. Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents. Biochem. Pharmacol. 73(10), 1558-1572 (2007).