An antiprotozoal agent
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Nithiamide

Item No. 36006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-nitro-2-thiazolyl)-acetamide
CAS Number
140-40-9
Synonyms
  • 2-Acetylamino-5-nitrothiazole
  • Aminitrozole
  • CL 5,279
  • NSC 31539
  • NSC 45914
Molecular Formula
C5H5N3O3S
Formula Weight
187.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
235, 339 nm
SMILES
O=C(C)NC1=NC=C([N+]([O-])=O)S1
InChi Code
InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
InChi Key
UJRRDDHEMZLWFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $99

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    Cayman Chemical
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    Product Description

    Nithiamide is an antiprotozoal agent.1 It is active against G. intestinalis and T. vaginalis (IC50s = 0.49 and 0.022 µM, respectively). Nithiamide (0.05% in the diet) reduces mortality in a turkey model of histomoniasis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Navarrete-Vázquez, G., Chávez-Silva, F., Colín-Lozano, B., et al. Synthesis of nitro(benzo)thiazole acetamides and in vitro antiprotozoal effect against amitochondriate parasites Giardia intestinalis and Trichomonas vaginalis. Bioorg. Med. Chem. 23(9), 2204-2210 (2015).

    2. Flowers, A.I., Hall, C.F., and Grumbles, L.C. Chemotherapy of histomoniasis of turkeys I. The Value of 1:2-dimethyl-5-nitroimidazole in prevention and treatment. Avian Dis. 9(3), 394-400 (1965).