A TRPM4 inhibitor
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TRPM4-IN-5

Item No. 36019

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-benzoic acid
CAS Number
351424-20-9
Synonyms
  • CBA
  • Transient Receptor Potential Melastatin 4 Inhibitor 5
  • TRPM4 Inhibitor 5
Molecular Formula
C15H11Cl2NO4
Formula Weight
340.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
230, 256 nm
SMILES
O=C(C1=C(NC(COC2=C(Cl)C=CC=C2)=O)C=C(Cl)C=C1)O
InChi Code
InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
InChi Key
CVQCJPCMPGKEDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $87

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    25 mg

    $206

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    Product Description

    TRPM4-IN-5 is an inhibitor of transient receptor potential melastatin 4 (TRPM4; IC50 = 1.5 µM in HEK293 cells expressing TRPM4).1 It is selective for TRPM4 over TRPM5 at 10 µM and TRPM7, TRPM8, transient receptor potential vanilloid 1 (TRPV1), and TRPV6 at 100 µM, as well as a panel of 17 other ion channels and receptors at 10 µM. TRPM4-IN-5 (50 µM) inhibits persistent firing in isolated mouse thalamic slices stimulated with the small conductance calcium-activated potassium channel (KCa2.2/SK2) inhibitor apamin (Item No. 17082).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ozhathil, L.C., Delalande, C., Bianchi, B., et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br. J. Pharmacol. 175(12), 2504-2519 (2018).

    2. O'Malley, J.J., Seibt, F., Chin, J., et al. TRPM4 conductances in thalamic reticular nucleus neurons generate persistent firing during slow oscillations. J. Neurosci. 40(25), 4813-4823 (2020).