A triterpene with diverse biological activities
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Tumulosic Acid

Item No. 36021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,16α)-3,16-dihydroxy-24-methylene-lanost-8-en-21-oic acid
CAS Number
508-24-7
Synonyms
  • Polyporenic Acid B
Molecular Formula
C31H50O4
Formula Weight
486.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)C
InChi Code
InChI=1S/C31H50O4/c1-18(2)19(3)9-10-20(27(34)35)26-23(32)17-31(8)22-11-12-24-28(4,5)25(33)14-15-29(24,6)21(22)13-16-30(26,31)7/h18,20,23-26,32-33H,3,9-17H2,1-2,4-8H3,(H,34,35)/t20-,23-,24+,25+,26+,29-,30-,31+/m1/s1
InChi Key
XADJANKGURNTIA-YEXRKOARSA-N
Origin
Fungus/Poria cocos
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $93

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    5 mg

    $315

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    Product Description

    Tumulosic acid is a triterpene that has been found in Poria cocos and has diverse biological activities.1,2,3,4 It inhibits DNA topoisomerase I and II by 83.3 and 75.5%, respectively, when used at a concentration of 100 µM.1 Tumulosic acid also inhibits kallikrein 5 and trypsin but not kallikrein 7 or chymotrypsin C (IC50s = 14.8, 45.3, >100, and >100 µM for the human enzymes, respectively).2 It inhibits LPS-induced nitric oxide (NO) production (IC50 = 42.5 µM) and activator protein 1 (AP-1) transcriptional activity in RAW 264.7 macrophages.3 Tumulosic acid (30 µg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, L., Xu, M.-L., Lee, C.-S., et al. Cytotoxicity and DNA topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocos. Arch. Pharm. Res. 27(8), 829-833 (2004).

    2. Matsubara, Y., Matsumoto, T., Koseki, J., et al. Inhibition of human kallikrein 5 protease by triterpenoids from natural sources. Molecules 22(11), 1829 (2017).

    3. Cai, T.-G., and Cai, Y. Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathway. Chem. Biodivers. 8(11), 2135-2143 (2011).

    4. Nukaya, H., Yamashiro, H., Fukazawa, H., et al. Isolation of inhibitors of TPA-induce mouse ear edema from Hoelen Poria cocos. Chem. Pharm. Bull. (Tokyo) 44(4), 847-849 (1996).