An inhibitor of ACCS2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acetyl-CoA Synthase Inhibitor

Item No. 36023

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-di-2-thienyl-6-quinoxalinyl)-N′-(2-methoxyethyl)-urea
CAS Number
508186-14-9
Synonyms
  • ACCS2 Inhibitor
  • MDK6149
  • VY-3-249
Molecular Formula
C20H18N4O2S2
Formula Weight
410.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
221, 273, 400 nm
SMILES
O=C(NCCOC)NC1=CC2=C(N=C(C3=CC=CS3)C(C4=CC=CS4)=N2)C=C1
InChi Code
InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25)
InChi Key
CTPVNWVUAGMHEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $110

    Add

    10 mg

    $178

    Add

    25 mg

    $248

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Acetyl-CoA synthase inhibitor is an inhibitor of acetyl-CoA synthetase 2 (ACCS2; IC50 = 1.214 µM).1 It reduces oleic acid-induced increases in the number of histone H2AX-positive cells, a marker of DNA damage, in cultured human immortalized hepatocytes when used at a concentration of 50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schug, Z., and Salvino, J. Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same. (2020).

    2. Assante, G., Chandrasekaran, S., Ng, S., et al. Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease. Genome Med. 14(1), 67 (2022).