A neurotrophic agent
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Edonerpic (maleate)

Item No. 36026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-(2-benzo[b]thien-5-ylethoxy)propyl]-3-azetidinol, 2Z-butenedioate
CAS Number
519187-97-4
Synonyms
  • T-187MA
Molecular Formula
C16H21NO2S • C4H4O4
Formula Weight
407.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
229 nm
SMILES
OC(C1)CN1CCCOCCC2=CC=C(SC=C3)C3=C2.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C16H21NO2S.C4H4O4/c18-15-11-17(12-15)6-1-7-19-8-4-13-2-3-16-14(10-13)5-9-20-16;5-3(6)1-2-4(7)8/h2-3,5,9-10,15,18H,1,4,6-8,11-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
RLUCYBFCLXANSO-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

    $178

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    25 mg

    $391

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    Product Description

    Edonerpic is a neurotrophic agent.1 It protects against sodium nitroprusside-induced mitochondrial dysfunction and apoptosis in primary rat cortical neurons when used at concentrations of 0.1 and 1 µM. Edonerpic (8.4 mg/kg per day, p.o.) prevents granule cell loss induced by amyloid-β (1-40) (Aβ40) and improves performance in the distance movement, random reward place search, and place learning tasks in rats.2 It also increases hippocampal neurogenesis and ameliorates Aβ40-induced spatial learning impairments in a rat model of Alzheimer’s disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukushima, T., Koide, M., Ago, Y., et al. T-817MA, a novel neurotrophic agent, improves sodium nitroprusside-induced mitochondrial dysfunction in cortical neurons. Neurochem. Int. 48(2), 124-130 (2006).

    2. Nguyen, P.T., Kimura, T., Ho, S.A., et al. Ameliorative effects of a neuroprotective agent, T-817MA, on place learning deficits induced by continuous infusion of amyloid-beta peptide (1-40) in rats. Hippocampus 17(6), 443-455 (2007).

    3. Kimura, T., Nguyen, P.T.H., Ho, S.A., et al. T-817MA, a neurotrophic agent, ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-β peptide. Br. J. Pharmacol. 157(3), 451-463 (2009).