An active metabolite of estrone
Related Products
Isomer(s)
341552-methoxy Estrone
Parent Compound(s)
10006485Estrone
Technical Support & Resources

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4-methoxy Estrone

Item No. 36041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-4-methoxy-estra-1,3,5(10)-trien-17-one
CAS Number
58562-33-7
Synonyms
  • 4-MeOE1
  • 4-methoxy E1
Molecular Formula
C19H24O3
Formula Weight
300.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(OC)=C4CC3
InChi Code
InChI=1S/C19H24O3/c1-19-10-9-12-11-5-7-16(20)18(22-2)14(11)4-3-13(12)15(19)6-8-17(19)21/h5,7,12-13,15,20H,3-4,6,8-10H2,1-2H3/t12-,13-,15+,19+/m1/s1
InChi Key
PUEXVLNGOBYUEW-BFDPJXHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $51

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    1 mg

    $77

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    5 mg

    $229

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    Product Description

    4-methoxy Estrone is an active metabolite of the endogenous estrogen estrone (Item No. 10006485).1 It is formed from estrone by catechol-O-methyltransferase (COMT). 4-methoxy Estrone (10 and 100 nM) increases the proliferation of human umbilical vein endothelial cells (HUVECs).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dawling, S., Roodi, N., Mernaugh, R.L., et al. Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoforms. Cancer Res. 61(18), 6716-6722 (2001).

    2. Lippert, C., Seeger, H., Mueck, A.O., et al. The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells. Life Sci. 67(13), 1653-1658 (2000).