A derivative of INH1 with anticancer activity

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Product Type

Biochemicals

Research Area

Cancer

Cell Death

Application

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide

Name: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide
Brand: -

Item No. 36050

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide (Nec2/Hec1 Inhibitor, CAS Number: 560103-80-2)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

N-(4-(2,4-dimethylphenyl)thiazol-2-yl)isonicotinamide

CAS Number

560103-80-2

Synonyms

Nec2/Hec1 Inhibitor

Molecular Formula

C₁₇H₁₅N₃OS

Formula Weight

309.4

Purity

≥98%

Formulation (Request formulation change)

A solid

Solubility(Learn about Variance in Solubility)

DMSO: soluble

SMILES

CC1=C(C=CC(C)=C1)C2=CSC(NC(C3=CC=NC=C3)=O)=N2

InChi Code

InChI=1S/C17H15N3OS/c1-11-3-4-14(12(2)9-11)15-10-22-17(19-15)20-16(21)13-5-7-18-8-6-13/h3-10H,1-2H3,(H,19,20,21)

InChi Key

IBQLKKBLBXJSGU-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

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1 mg

$32

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5 mg

$141

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10 mg

$248

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25 mg

$542

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Product Description

N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 (Item No. 29015) with anticancer activity.¹ It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC₅₀s = 1.1, 3.4, 1.6, and 1.2 µM, respectively).

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Qiu, X.-L., Li, G., Wu, G., et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J. Med. Chem. 52(6), 1757-1767 (2009).

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