An active metabolite of camostat
Related Products
Pro-drug Form(s)
16018Camostat (mesylate)
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FOY-251

Item No. 36051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, monomethanesulfonate
CAS Number
71079-09-9
Molecular Formula
C16H15N3O4 • CH3SO3H
Formula Weight
409.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/ml
λmax
266 nm
SMILES
O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O
InChi Code
InChI=1S/C16H15N3O4.CH4O3S/c17-16(18)19-12-5-3-11(4-6-12)15(22)23-13-7-1-10(2-8-13)9-14(20)21;1-5(2,3)4/h1-8H,9H2,(H,20,21)(H4,17,18,19);1H3,(H,2,3,4)
InChi Key
JXMOPIDYHUYOED-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $44

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    FOY-251 is an active metabolite of the antiviral protease inhibitor camostat (Item No. 16018).1 It inhibits transmembrane serine protease 2 (TMPRSS2; IC50 = 33.3 nM).2 FOY-251 inhibits entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudotyped particles in Calu-3 cells (EC50 = 178 nM) and reduces viral titers in SARS-CoV-2-infected Calu-3 cells when used at concentrations ranging from 1 to 10 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, M., Hofmann-Winkler, H., Smith, J.C., et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine 65, 103255 (2021).

    2. Shrimp, J.H., Kales, S.C., Sanderson, P.E., et al. An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19. bioRxiv 167544 (2020).