An ACL inhibitor
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NDI-091143

Item No. 36054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-chloro-5-[[(4,6-difluoro[1,1′-biphenyl]-3-yl)amino]sulfonyl]-4-hydroxy-benzoic acid, methyl ester
CAS Number
2375840-87-0
Molecular Formula
C20H14ClF2NO5S
Formula Weight
453.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 1 mg/ml
λmax
292 nm
SMILES
O=C(C1=CC(Cl)=C(C(S(=O)(NC2=CC(C3=CC=CC=C3)=C(C=C2F)F)=O)=C1)O)OC
InChi Code
InChI=1S/C20H14ClF2NO5S/c1-29-20(26)12-7-14(21)19(25)18(8-12)30(27,28)24-17-9-13(15(22)10-16(17)23)11-5-3-2-4-6-11/h2-10,24-25H,1H3
InChi Key
YSTSHUWHIDBZAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $124

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    25 mg

    $244

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    50 mg

    $455

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    Product Description

    NDI-091143 is an allosteric inhibitor of ATP citrate lyase (ACL; Ki = 7 nM).1 It inhibits the production of ADP in a cell-free assay and oxaloacetate production in an enzyme-coupled assay (IC50s = 2.1 and 4.8 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wei, J., Leit, S., Kuai, J., et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature 568(7753), 566-570 (2019).