An AT1 and AT2 receptor agonist and active metabolite of angiotensin II
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Angiotensin A (trifluoroacetate salt)

Item No. 36063

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine, trifluoroacetate salt
Synonyms
  • Ala-Arg-Val-Tyr-Ile-His-Pro-Phe
  • Des[Asp1]-[Ala1]-Ang II
Molecular Formula
C49H71N13O10 • XCF3COOH
Formula Weight
1002.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](N)C)=O)CCCNC(N)=N)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C49H71N13O10.C2HF3O2/c1-6-28(4)40(46(69)58-36(24-32-25-53-26-55-32)47(70)62-21-11-15-38(62)44(67)59-37(48(71)72)23-30-12-8-7-9-13-30)61-43(66)35(22-31-16-18-33(63)19-17-31)57-45(68)39(27(2)3)60-42(65)34(56-41(64)29(5)50)14-10-20-54-49(51)52;3-2(4,5)1(6)7/h7-9,12-13,16-19,25-29,34-40,63H,6,10-11,14-15,20-24,50H2,1-5H3,(H,53,55)(H,56,64)(H,57,68)(H,58,69)(H,59,67)(H,60,65)(H,61,66)(H,71,72)(H4,51,52,54);(H,6,7)/t28-,29-,34-,35-,36-,37-,38-,39-,40-;/m0./s1
InChi Key
LCONVIIMBYELIZ-HNAHIYLQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $207

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    25 mg

    $490

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    Product Description

    Angiotensin A is an angiotensin II type 1 (AT1) and AT2 receptor agonist and active metabolite of the peptide hormone angiotensin II (Item No. 17150).1 It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC50 = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by the AT1 antagonist EXP-3174 (losartan carboxylic acid; Item No. 15957). The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jankowski, V., Vanholder, R., van der Giet, M., et al. Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Arterioscler. Thromb. Vasc. Biol. 27(2), 297-302 (2007).

    2. Sandoval, J., Del Valle-Mondragón, L., Masso, F., et al. Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension. Eur. Respir. J. 56(1), 1902416 (2020).