An OGG1 inhibitor
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SU 0268

Item No. 36064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-[1,1′-biphenyl]-3-carboxamide
CAS Number
2210228-45-6
Molecular Formula
C26H25N3O4S
Formula Weight
475.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): insol
λmax
254 nm
SMILES
O=C(C1=CC(C2=CC=C(S(=O)(NC3=CC=C4C(N(CCC4)C(C5CC5)=O)=C3)=O)C=C2)=CC=C1)N
InChi Code
InChI=1S/C26H25N3O4S/c27-25(30)21-4-1-3-20(15-21)17-9-12-23(13-10-17)34(32,33)28-22-11-8-18-5-2-14-29(24(18)16-22)26(31)19-6-7-19/h1,3-4,8-13,15-16,19,28H,2,5-7,14H2,(H2,27,30)
InChi Key
XGGNCZLDTJOSFV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $217

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    25 mg

    $502

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    Cayman Chemical
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    Product Description

    SU 0268 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1; IC50 = 0.059 µM).1 It is selective for OGG1 over the DNA repair enzymes MTH1, dUTPase, NUDT16, ABH2, ABH3, and SMUG1 at 20 µM. SU 0268 (0.5 µM) inhibits OGG1 and increases the number of 8-oxoguanine DNA lesions in HeLa cell lysates.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tahara, Y.-K., Auld, D., Ji, D., et al. Potent and selective inhibitors of 8-oxoguanine DNA glycosylase. J. Am. Chem. Soc. 140(6), 2105-2114 (2018).