A furin inhibitor
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Hexa-D-Arginine (trifluoroacetate salt)

Item No. 36065

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide, trifluoroacetate salt
Synonyms
  • Furin Inhibitor II
  • Hexa-D-Arg-NH2
  • Hexa-D-Arginine amide
  • D6R-NH2
  • (D)RRRRRR-NH2
Molecular Formula
C36H75N25O6 • XCF3COOH
Formula Weight
954.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile/H2O (80:20): 1 mg/ml
SMILES
N=C(N)NCCC[C@@H](N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C36H75N25O6.C2HF3O2/c37-19(7-1-13-51-31(39)40)26(63)58-21(9-3-15-53-33(43)44)28(65)60-23(11-5-17-55-35(47)48)30(67)61-24(12-6-18-56-36(49)50)29(66)59-22(10-4-16-54-34(45)46)27(64)57-20(25(38)62)8-2-14-52-32(41)42;3-2(4,5)1(6)7/h19-24H,1-18,37H2,(H2,38,62)(H,57,64)(H,58,63)(H,59,66)(H,60,65)(H,61,67)(H4,39,40,51)(H4,41,42,52)(H4,43,44,53)(H4,45,46,54)(H4,47,48,55)(H4,49,50,56);(H,6,7)/t19-,20-,21-,22-,23-,24-;/m1./s1
InChi Key
PWFVPQZWAYQQHX-MZYAMQFBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Cayman Chemical
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    Product Description

    Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki = 100 nM).1 It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki = 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels, markers of the epithelial-to-mesenchymal transition (EMT), in the same cells.2 It improves survival in a rat model of anthrax toxemia induced by the anthrax toxins protective antigen and lethal factor.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shiryaev, S.A., Ratnikov, B.I., Chekanov, A.V., et al. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem. J. 393(Pt 2), 503-511 (2006).

    2. Zhou, M., Zhang, Y., Wei, H., et al. Furin inhibitor D6R suppresses epithelial‑mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo‑YAP signaling pathway. Oncol. Lett. 15(3), 3192-3196 (2018).

    3. Sarac, M.S., Peinado, J.R., Leppla, S.H., et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect. Immun. 72(1), 605-605 (2004).