A cell-permeable form of NFAT inhibitor
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NFAT Inhibitor (cell-permeable) (trifluoroacetate salt)

Item No. 36066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycylglycyl-L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid
Synonyms
  • Nuclear Factor Activated T cells Inhibitor
  • RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
  • 11R-VIVIT
Molecular Formula
C147H259N67O36S • XCF3COOH
Formula Weight
3573.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleWater: soluble
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(NCC(N[C@@H](CCSC)C(N[C@H](C(NCC(N1CCC[C@H]1C(N[C@@H](CC2=CNC=N2)C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(N[C@@](C(N[C@@H](C(C)C)C(N[C@@](C(N[C@]([C@H](O)C)([H])C(NCC(N4CCC[C@H]4C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC=O)C(O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N[H].FC(F)(C(O)=O)F
InChi Code
InChI=1S/C147H259N67O35S.C2HF3O2/c1-12-76(7)109(133(245)208-108(75(5)6)132(244)210-110(77(8)13-2)134(246)211-111(79(10)216)130(242)188-71-105(221)212-58-25-41-98(212)127(239)205-96(63-80-65-171-72-189-80)126(238)203-93(44-45-106(222)223)125(237)204-95(136(248)249)40-28-61-215)209-131(243)107(74(3)4)207-129(241)100-43-27-60-214(100)135(247)97(64-81-66-172-73-190-81)206-128(240)99-42-26-59-213(99)104(220)70-187-112(224)78(9)191-115(227)94(46-62-250-11)192-103(219)69-185-101(217)67-184-102(218)68-186-114(226)83(30-15-48-174-138(151)152)194-117(229)85(32-17-50-176-140(155)156)196-119(231)87(34-19-52-178-142(159)160)198-121(233)89(36-21-54-180-144(163)164)200-123(235)91(38-23-56-182-146(167)168)202-124(236)92(39-24-57-183-147(169)170)201-122(234)90(37-22-55-181-145(165)166)199-120(232)88(35-20-53-179-143(161)162)197-118(230)86(33-18-51-177-141(157)158)195-116(228)84(31-16-49-175-139(153)154)193-113(225)82(148)29-14-47-173-137(149)150;3-2(4,5)1(6)7/h61,65-66,72-79,82-100,107-111,216H,12-60,62-64,67-71,148H2,1-11H3,(H,171,189)(H,172,190)(H,184,218)(H,185,217)(H,186,226)(H,187,224)(H,188,242)(H,191,227)(H,192,219)(H,193,225)(H,194,229)(H,195,228)(H,196,231)(H,197,230)(H,198,233)(H,199,232)(H,200,235)(H,201,234)(H,202,236)(H,203,238)(H,204,237)(H,205,239)(H,206,240)(H,207,241)(H,208,245)(H,209,243)(H,210,244)(H,211,246)(H,222,223)(H,248,249)(H4,149,150,173)(H4,151,152,174)(H4,153,154,175)(H4,155,156,176)(H4,157,158,177)(H4,159,160,178)(H4,161,162,179)(H4,163,164,180)(H4,165,166,181)(H4,167,168,182)(H4,169,170,183);(H,6,7)/t76-,77-,78-,79+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-,110-,111-;/m0./s1
InChi Key
KOURFUYLBUTWHC-PVBPKFJUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    NFAT inhibitor (cell-permeable) is a cell-permeable form of NFAT inhibitor (Item No. 13855), an inhibitor of calcineurin-nuclear factor of activated T cells (NFAT) signaling.1 It inhibits the production of IL-12p40 and nitric oxide (NO) in LPS- and IFN-γ-induced mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. NFAT inhibitor (cell-permeable) (1 mg/kg) prevents increases in kidney weight and urine albumin levels in a db/db mouse model of diabetic nephropathy.2 It improves fracture healing in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 100 µg/kg for 16 weeks post-fracture.3 NFAT inhibitor (cell-permeable) (1 mg/kg) decreases disease severity in IL-10 knockout mice in a model of colitis induced by piroxicam (Item No. 13368).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elloumi, H.Z., Maharshak, N., Rao, K.N., et al. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7(3), e34172 (2012).

    2. Zhang, L., Li, R., Shi, W., et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br. J. Pharmacol. 170(2), 426-439 (2013).

    3. Hou, C., Wang, X., Jiang, W., et al. Peptide 11R‑VIVIT promotes fracture healing in osteoporotic rats. Int. J. Mol. Med. 48(2), 162 (2021).