A cephalosporin antibiotic
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Ceforanide

Item No. 36075

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
60925-61-3
Synonyms
  • BL-S 786
Molecular Formula
C20H21N7O6S2
Formula Weight
519.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(N[C@H]1[C@](SCC(CSC2=NN=NN2CC(O)=O)=C3C(O)=O)([H])N3C1=O)CC4=C(CN)C=CC=C4
InChi Code
InChI=1S/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1
InChi Key
SLAYUXIURFNXPG-CRAIPNDOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Ceforanide is a cephalosporin antibiotic.1 It is active against the Gram-positive bacteria S. pyogenes, S. pneumoniae, V. streptococci, S. aureus, and S. epidermidis (MICs = 0.5, 0.2-0.5, 2, 8, and 6.2 µg/ml, respectively), as well as the Gram-negative bacteria E. coli, P. mirabilis, and K. pneumoniae (MIC50s = 1.6, 0.8, and 1.6 µg/ml, respectively). In vivo, ceforanide (30 mg/kg) reduces the number of colony forming units (CFUs) in vegetations and increases survival in a rabbit model of S. aureus-induced endocarditis.2 Formulations containing ceforanide have been used in the treatment of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barriere, S.L., and Mills, J. Ceforanide: Antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy 2(6), 322-327 (1982).

    2. Carrizosa, J., Kobasa, W.D., and Kaye, D. Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits. Antimicrob Agents Chemother. 18(4), 562-565 (1980).