A hair follicle stimulator and an active metabolite of minoxidil
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Parent Compound(s)
15302Minoxidil
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Minoxidil Sulfate

Item No. 36084

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine
CAS Number
83701-22-8
Synonyms
  • U-58838
Molecular Formula
C9H15N5O4S
Formula Weight
289.3
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: Slightly solubleAcetonitrile: Slightly solubleDMSO: Slightly soluble
SMILES
O=S(O)(ON1C(C=C(N2CCCCC2)N=C1N)=N)=O
InChi Code
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChi Key
KVOZMWUBYWDGEX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $33

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    5 mg

    $106

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    10 mg

    $131

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    Product Description

    Minoxidil sulfate is a hair follicle stimulator and an active metabolite of the vasodilator minoxidil (Item No. 15302).1 It is formed from minoxidil by sulfotransferase 1A1 (SULT1A1) in the liver and hair root sheath.2,3,4 Minoxidil sulfate binds to ATP sensitive K+ (KATP) channels in a biphasic manner in COS-7 cells expressing the human channel with IC50 values of 0.62 and 0.96 µM.5,6 It induces vasodilation in isolated rabbit mesenteric artery when used at a concentration of 5 µM.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buhl, A.E., Waldon, D.J., Baker, C.A., et al. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J. Invest. Dermatol. 95(5), 553-557 (1990).

    2. Falany, C.N., and Kerl, E.A. Sulfation of minoxidil by human liver phenol sulfotransferase. Biochem. Pharmacol. 40(5), 1027-1032 (1990).

    3. Johnson, G.A., and Baker, C.A. Sulfation of minoxidil by human platelet sulfotransferase. Clin. Chim. Acta 169(2-3), 217-227 (1987).

    4. Dooley, T.P., Walker, C.J., Hirshey, S.J., et al. Localization of minoxidil sulfotransferase in rat liver and the outer root sheath of anagen pelage and vibrissa follicles. J. Invest. Dermatol. 96(1), 65-70 (1991).

    5. Meisheri, K.D., Oleynek, J.J., and Puddington, L. Role of protein sulfation in vasodilation induced by minoxidil sulfate, a K+ channel opener. J. Pharmacol. Exp. Ther. 258(3), 1091-1097 (1991).

    6. Schwanstecher, M., Sieverding, C., Dörschner, H., et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 17(19), 5529-5535 (1998).