A 5-HT2C receptor agonist
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MK-212 (hydrochloride)

Item No. 36089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-6-(1-piperazinyl)-pyrazine, monohydrochloride
CAS Number
61655-58-1
Molecular Formula
C8H11ClN4 • HCl
Formula Weight
235.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly solubleWater: Slightly soluble
λmax
250, 329 nm
SMILES
ClC1=CN=CC(N2CCNCC2)=N1.Cl
InChi Code
InChI=1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
InChi Key
PFIZGLUIYAZQFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $94

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    10 mg

    $131

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    50 mg

    $556

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    100 mg

    $1,020

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    Product Description

    MK-212 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C (EC50 = 0.028 µM in a calcium mobilization assay).1 It is selective for 5-HT2C over 5-HT2A receptors (EC50 = 0.42 µM). MK-212 reduces food intake in fasted rats with an ED50 value of 5 mg/kg.2 It reduces cocaine-primed reinstatement of cocaine-seeking behavior in rats when administered at doses of 0.32, 0.56, or 1 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jensen, A.A., Plath, N., Pedersen, M.H.F., et al. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: Novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J. Med. Chem. 56(3), 1211-1227 (2013).

    2. J.C., H., Lawton, C.L., and Blundell, J.E. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol. Biochem. Behav. 56(1), 41-46 (1997).

    3. Neisewander, J.L., and Acosta, J.I. Stimulation of 5-HT2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats. Behav. Pharmacol. 18(8), 791-800 (2007).