A cephalosporin antibiotic
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Ceftizoxime (sodium salt)

Item No. 36093

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
CAS Number
68401-82-1
Synonyms
  • FR 13479
Molecular Formula
C13H12N5O5S2 • Na
Formula Weight
405.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
230 nm
SMILES
[H][C@]12SCC=C(C([O-])=O)N1C([C@H]2NC(/C(C3=CSC(N)=N3)=N\OC)=O)=O.[Na+]
InChi Code
InChI=1S/C13H13N5O5S2.Na/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18;/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22);/q;+1/p-1/b17-7-;/t8-,11-;/m1./s1
InChi Key
ADLFUPFRVXCDMO-LIGXYSTNSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ceftizoxime is a cephalosporin antibiotic.1 Ceftizoxime is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, and S. epidermidis (IC50s = 1.56, ≤0.025, and 0.78 µg/ml, respectively), as well as clinical isolates of the Gram-negative bacteria E. coli, K. pneumoniae, and P. mirabilis (IC50s = 0.1, ≤0.025, and ≤0.025 µg/ml, respectively). It is protective against S. aureus, E. coli, P. mirabilis, or P. vulgaris infection in mice (ED50s = 4.03, 0.02, 0.255, and 0.038 mg/kg, respectively).2 Formulations containing ceftizoxime have been used in the treatment of a variety of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kamimura, T., Matsumoto, Y., Okada, N., et al. Ceftizoxime (FK 749), a new parenteral cephalosporin: In vitro and in vivo antibacterial activities. Antimicrob. Agents Chemother. 16(5), 540-548 (1979).

    2. Nishida, M., Kamimura, T., Okada, N., et al. Comparison of antibacterial activity of a new cephalosporin, ceftizoxime (FK 749) with other cephalosporin antibiotics. J. Antibiot. (Tokyo) 32(12), 1319-1327 (1979).