An agonist of GPR139
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TAK-041

Item No. 36108

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]-1,2,3-benzotriazine-3(4H)-acetamide
CAS Number
1929519-13-0
Synonyms
  • NBI 1065864
Molecular Formula
C18H15F3N4O3
Formula Weight
392.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/ml
SMILES
O=C1C2=CC=CC=C2N=NN1CC(N[C@H](C3=CC=C(C=C3)OC(F)(F)F)C)=O
InChi Code
InChI=1S/C18H15F3N4O3/c1-11(12-6-8-13(9-7-12)28-18(19,20)21)22-16(26)10-25-17(27)14-4-2-3-5-15(14)23-24-25/h2-9,11H,10H2,1H3,(H,22,26)/t11-/m0/s1
InChi Key
JZGLECLGVQRPPI-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $123

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    10 mg

    $192

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    25 mg

    $433

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    Product Description

    TAK-041 is an agonist of G protein-coupled receptor 139 (GPR139).1 It induces calcium mobilization in cells expressing human GPR139 (EC50 = 22 nM). In vivo, TAK-041 (0.3 and 3 mg/kg) increases social interaction in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reichard, H.A., Schiffer, H.H., Monenschein, H., et al. Discovery of TAK-041: A potent and selective GPR139 agonist explored for the treatment of negative symptoms associated with schizophrenia. J. Med. Chem. 64(15), 11527-11542 (2021).