A glutaminyl cyclase inhibitor
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PBD-150

Item No. 36112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3,4-dimethoxyphenyl)-N′-[3-(1H-imidazol-1-yl)propyl]-thiourea
CAS Number
790663-33-1
Molecular Formula
C15H20N4O2S
Formula Weight
320.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
249 nm
SMILES
S=C(NCCCN1C=NC=C1)NC2=CC(OC)=C(OC)C=C2
InChi Code
InChI=1S/C15H20N4O2S/c1-20-13-5-4-12(10-14(13)21-2)18-15(22)17-6-3-8-19-9-7-16-11-19/h4-5,7,9-11H,3,6,8H2,1-2H3,(H2,17,18,22)
InChi Key
FZQXMGLQANXZRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $47

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    10 mg

    $71

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    50 mg

    $275

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    100 mg

    $413

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    Product Description

    PBD-150 is an inhibitor of glutaminyl cyclase (Ki = 0.49 µM for the human enzyme).1 It inhibits the formation of the pyroglutamic acid-containing amyloid-β (Aβ) peptides pGlu-Aβ (3-40) and pGlu-Aβ (3-42) in HEK293 cells expressing human glutaminyl cyclase and human amyloid precursor protein (APP) with an N-terminal deletion of the first two amino acids.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buchholz, M., Heiser, U., Schilling, S., et al. The first potent inhibitors for human glutaminyl cyclase: Synthesis and structure-activity relationship. J. Med. Chem. 49(2), 664-677 (2006).