An inhibitor of SARS-CoV and SARS-CoV-2 Mpro
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GRL-0496

Item No. 36114

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester
CAS Number
1087243-14-8
Molecular Formula
C14H9ClN2O2
Formula Weight
272.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlEthanol: 25 mg/ml
λmax
212, 230 nm
SMILES
O=C(C1=C2C=CNC2=CC=C1)OC3=CN=CC(Cl)=C3
InChi Code
InChI=1S/C14H9ClN2O2/c15-9-6-10(8-16-7-9)19-14(18)12-2-1-3-13-11(12)4-5-17-13/h1-8,17H
InChi Key
BOSZJNSICHFHMA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $148

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    10 mg

    $279

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    Cayman Chemical
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    Product Description

    GRL-0496 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro; IC50s = 0.03 and 0.038 µM, respectively).1,2 It reduces viral infectivity in SARS-CoV-infected Vero cells (EC50 = 6.9 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ghosh, A.K., Gong, G., Grum-Tokars, V., et al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg. Med. Chem. Lett. 18(20), 5684-5688 (2008).

    2. Cao, W., Cho, C.-C.D., Geng, Z.Z., et al. Evaluation of SARS-CoV-2 main protease inhibitors using a novel cell-based assay. ACS Cent. Sci. 8(2), 192-204 (2022).