A DUSP26 inhibitor
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F1063-0967

Item No. 36115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-4-[[6-[5-[(4-methylphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxohexyl]amino]-benzoic acid
CAS Number
613225-56-2
Molecular Formula
C24H24N2O5S2
Formula Weight
484.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: slightly soluble
λmax
275, 303, 384 nm
SMILES
O=C(C1=CC=C(NC(CCCCCN2C(SC(C2=O)=CC3=CC=C(C)C=C3)=S)=O)C=C1O)O
InChi Code
InChI=1S/C24H24N2O5S2/c1-15-6-8-16(9-7-15)13-20-22(29)26(24(32)33-20)12-4-2-3-5-21(28)25-17-10-11-18(23(30)31)19(27)14-17/h6-11,13-14,27H,2-5,12H2,1H3,(H,25,28)(H,30,31)
InChi Key
RNICWTYEMLCCAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    F1063-0967 is an inhibitor of dual-specificity phosphatase 26 (DUSP26; IC50 = 11.62 µM).1 It induces IMR-32 neuroblastoma cell apoptosis (IC50 = 4.13 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, J.-X., Cheng, Z., Huang, Y.-X., et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed. Pharmacother. 89, 376-385 (2017).