An agonist of α7 nAChRs
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SEN-12333

Item No. 36123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
CAS Number
874450-44-9
Synonyms
  • WAY-317538
Molecular Formula
C20H25N3O2
Formula Weight
339.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): insol
λmax
282 nm
SMILES
O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2
InChi Code
InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24)
InChi Key
XCHIZTUBUXZESJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $124

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    50 mg

    $522

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    100 mg

    $919

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    Product Description

    SEN-12333 is an agonist of α7 nicotinic acetylcholine receptors (nAChRs; Ki = 0.26 µM).1 It is selective for α7 nAChRs over α1-, α3-, and α4β2 subunit-containing nAChRs and the serotonin (5-HT) receptor subtype 5-HT3, as well as a panel of 70 additional neurotransmitter, growth factor, and peptide receptors at 10 µM. SEN-12333 activates the α7 nAChR in GH4C1 cells expressing the rat receptor (EC50 = 1.6 µM). Topical application of SEN-12333 prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma in a concentration-dependent manner.2 SEN-12333 (3 mg/kg) reverses scopolamine- or MK-801-induced memory deficits in the novel object recognition test in rats.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haydar, S.N., Ghiron, C., Bettinetti, L., et al. SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist. Bioorg. Med. Chem. 17(14), 5247-5258 (2009).

    2. Birkholz, P.J., Gossman, C.A., Webster, M.K., et al. Prevention of glaucoma-induced retinal ganglion cell loss using alpha7 nAChR agonists. J. Ophthalmol. Vis. Sci. 1(1), 1003 (2016).