An inhibitor of the RUVBL1/2 complex
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CB-6644

Item No. 36125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-[4-[[6,7-dihydro-3-(methoxymethyl)-1-oxo-1H,5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]-2-ethoxy-4-fluoro-benzamide
CAS Number
2316817-88-4
Molecular Formula
C29H34ClFN4O5
Formula Weight
573.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
230 nm
SMILES
O=C(C1=CC(Cl)=C(C=C1OCC)F)NCC(C)(CC(NC2=C(COC)N3CCCC4=C(C=CC=C4)N3C2=O)=O)C
InChi Code
InChI=1S/C29H34ClFN4O5/c1-5-40-24-14-21(31)20(30)13-19(24)27(37)32-17-29(2,3)15-25(36)33-26-23(16-39-4)34-12-8-10-18-9-6-7-11-22(18)35(34)28(26)38/h6-7,9,11,13-14H,5,8,10,12,15-17H2,1-4H3,(H,32,37)(H,33,36)
InChi Key
VYCOZEBCSAQCES-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    CB-6644 is an inhibitor of the RUVBL1/2 complex, a complex with ATPase activity that regulates several cellular processes, including chromatin remodeling and gene expression.1 It inhibits the ATPase activity of the RUVBL1/2 complex (IC50 = 15 nM) and is selective for the RUVBL1/2 complex over a panel of 224 ATPases at 10 µM. CB-6644 reduces viability in a panel of cancer cell lines with EC50 values ranging from 41 to 785 nM. It induces apoptosis in HCT116 colon cancer cells when used at a concentration of 0.4 µM. CB-6644 (150 mg/kg) reduces tumor growth in Ramos Burkitt’s lymphoma and RPMI-8226 multiple myeloma xenograft mouse models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Assimon, V.A., Tang, Y., Vargas, J.D., et al. CB-6644 is a selective inhibitor of the RUVBL1/2 complex with anticancer activity. ACS Chem Biol. 14(2), 236-244 (2019).