A GAT inhibitor
Related Products
Isomer(s)
36313L-Pipecolic Acid
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Nipecotic Acid

Item No. 36126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-piperidinecarboxylic acid
CAS Number
498-95-3
Synonyms
  • (±)-Nipecotic Acid
  • (R,S)-Nipecotic Acid
  • 3-Piperidine Carboxylic Acid
  • DL-Piperidine 3-Carboxylic Acid
Molecular Formula
C6H11NO2
Formula Weight
129.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
O=C(C1CCCNC1)O
InChi Code
InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)
InChi Key
XJLSEXAGTJCILF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $32

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    250 mg

    $74

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    500 mg

    $141

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    Product Description

    Nipecotic acid is an inhibitor of GABA transporters (GAT; IC50s = 2.6, 310, 29, and 16 µM for mouse GAT-1, GAT-2, GAT-3, and GAT-4, respectively).1 It does not bind GABAA or GABAB receptors (IC50s = >100 µM for both) but does bind the adenosine A3 receptor (IC50 = 0.01 µM).2,3 Nipecotic acid inhibits GABA uptake in isolated rabbit choroid plexus (IC50 = 244 µM).4 It inhibits lactate dehydrogenase (LDH) release (EC50 = ~5 µM) and aggregation of a mutant form of huntingtin, htt-N63-148Q, in PC12 cells.5 Intraventricular administration of nipecotic acid (300 µg/animal) decreases tail flick reaction time in a rat model of morphine-induced analgesia.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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