A pentacyclic triterpene with diverse biological activities
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Taraxasterol Acetate

Item No. 36131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,18α,19α)-urs-20(30)-en-3-ol, 3-acetate
CAS Number
6426-43-3
Synonyms
  • NSC 401400
  • Taraxasteryl Acetate
Molecular Formula
C32H52O2
Formula Weight
468.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/ml (heat/sonication)
SMILES
C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C)=O)C)([H])CC2)C)([H])[C@]5([H])[C@@](CC3)(CCC([C@H]5C)=C)C)C
InChi Code
InChI=1S/C32H52O2/c1-20-12-15-29(6)18-19-31(8)23(27(29)21(20)2)10-11-25-30(7)16-14-26(34-22(3)33)28(4,5)24(30)13-17-32(25,31)9/h21,23-27H,1,10-19H2,2-9H3/t21-,23-,24+,25-,26+,27-,29-,30+,31-,32-/m1/s1
InChi Key
SFEUTIOWNUGQMZ-ZHLOSDGBSA-N
Origin
Plant/Inula britannica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Taraxasterol acetate is a pentacyclic triterpene that has been found in P. sagittalis and has diverse biological activities.1,2 It reduces the production of reactive oxygen species (ROS) and Hsp72 induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human neutrophils when used at concentrations of 10 and 100 µM and increases Hsp72 production in unstimulated isolated human neutrophils at 100 µM.1 Taraxasterol acetate (50 µg/ml) reduces protein levels of the E3 ubiquitin ligase RNF31 and increases levels of the autophagy marker LC3-I/II in HCT116 and SW480 cells.2 Topical administration of taraxasterol acetate (46 µg/ear) reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), croton oil, or PMA in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pérez-García, F., Marín, E., Parella, T., et al. Activity of taraxasteryl acetate on inflammation and heat shock protein synthesis. Phytomedicine 12(4), 278-284 (2005).

    2. Tang, C.-T., Yang, J., Liu, Z.-D., et al. Taraxasterol acetate targets RNF31 to inhibit RNF31/p53 axis-driven cell proliferation in colorectal cancer. Cell Death Discov. 7(1), 66 (2021).