A prodrug form of acetaminophen
Related Products
Active Metabolite(s)
10024Acetaminophen
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Propacetamol (hydrochloride)

Item No. 36134

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-glycine, 4-(acetylamino)phenyl ester, monohydrochloride
CAS Number
66532-86-3
Molecular Formula
C14H20N2O3 • HCl
Formula Weight
300.8
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
248 nm
SMILES
O=C(CN(CC)CC)OC1=CC=C(NC(C)=O)C=C1.Cl
InChi Code
InChI=1S/C14H20N2O3.ClH/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17;/h6-9H,4-5,10H2,1-3H3,(H,15,17);1H
InChi Key
WGTYJNGARJPYKG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $37

    Add

    250 mg

    $82

    Add

    500 mg

    $145

    Add

    1 g

    $181

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Propacetamol is a prodrug form of the analgesic and antipyretic agent acetaminophen (Item No. 10024).1 It is converted to acetaminophen by rat liver microsomes. Propacetamol reduces acetic acid-induced writhing in mice and LPS-induced pyresis in rats when administered at doses of 200 and 600 mg/kg, respectively.1,2 Propacetamol (1,200 mg/kg) induces hepatotoxicity, decreases hepatic glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPX) levels, increases hepatic malondialdehyde (MDA) and nitrotyrosine levels, and increases mortality in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murie, V.E., Marques, L.M.M., Souza, G.E.P., et al. Acetaminophen prodrug: Microwave-assisted synthesis and in vitro metabolism evaluation by mass spectrometry. J. Braz. Chem. Soc. 27(6), 1121-1128 (2016).

    2. Zhang , Y., Du, L., Pan, H., et al. Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice. Biol. Pharm. Bull. 34(3), 349-353 (2011).

    3. Liou, G.-G., Hsieh, C.-C., Lee, Y.-J., et al. N-Acetyl cysteine overdose inducing hepatic steatosis and systemic inflammation in both propacetamol-induced hepatotoxic and normal mice. Antioxidants (Basel) 10(3), 442 (2021).